A region of mumps virus nucleoprotein affects defective interfering particle production.

doi:10.1099/jgv.0.002085

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Article

A region of mumps virus nucleoprotein affects defective interfering particle production.

The Journal of general virology - 1 Apr 2025

Risalvato Jacquline, Zengel James, Phillips Mark, Beavis Ashley, Luo Ming, He Biao

Abstract excerpt

Mumps virus (MuV) is a negative-sense, single-stranded RNA virus belonging to the family Paramyxoviridae. MuV causes acute infection of the parotid glands, and the infection can result in severe cases of encephalitis, meningitis and deafness in humans. The non-segmented RNA genome of MuV is encapsidated by the nucleocapsid protein (NP), which forms the ribonucleoprotein (RNP) complex that serves as a template for...

Topics

Mumps virus
Nucleocapsid Proteins
Vero Cells
Chlorocebus aethiops
Animals
HEK293 Cells
Humans
RNA, Viral
Mutation
Phenotype
Virus Replication
Reverse Transcriptase Polymerase Chain Reaction
Defective Interfering Viruses
Conserved Sequence

Source

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Identifiers

PMID: 40214656
DOI: 10.1099/jgv.0.002085
PMCID: PMC11992363

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Amino Acid Sequence