Article
Evidence for a new viral late-domain core sequence, FPIV, necessary for budding of a paramyxovirus.
Journal of virology - 1 Mar 2005
Schmitt Anthony P, Leser George P, Morita Eiji, Sundquist Wesley I, Lamb Robert A
Abstract excerpt
Enveloped virus budding has been linked to both the ubiquitin-proteasome pathway and the vacuolar protein-sorting pathway of cells. We show here for the paramyxovirus SV5 that proteasome inhibitors and expression of dominant-negative VPS4(E228Q) ATPase blocks budding. The SV5 matrix (M) protein lacks previously defined late domains (e.g., P[T/S]AP, PPxY, YPDL) that recruit cellular factors. We identified a new...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
