Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

New syngeneic inflammatory-related lung cancer metastatic model harboring double KRAS/WWOX alterations.

International journal of cancer - 1 Dec 2014

Bleau Anne-Marie, Freire Javier, Pajares María José, Zudaire Isabel, Anton Iker, Nistal-Villán Estanislao, Redrado Miriam, Zandueta Caroli Na, Garmendia Irati, Ajona Daniel, Blanco David, Pio Ruben, Lecanda Fernando, Calvo Alfonso, Montuenga Luis M

Abstract excerpt

New mouse models with specific drivers of genetic alterations are needed for preclinical studies. Herein, we created and characterized at the genetic level a new syngeneic model for lung cancer and metastasis in Balb-c mice. Tumor cell lines were obtained from a silica-mediated airway chronic inflammation that promotes tumorigenesis when combined with low doses of N-nitrosodimethylamine, a tobacco smoke...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Comparative Genomic Hybridization
Share to Epithelial-Mesenchymal Transition

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoenzyme Techniques

Share to Mice, Nude

Share to Neoplasm Recurrence, Local

Share to Oxidoreductases

Share to WW Domain-Containing Oxidoreductase

Share to Xenograft Model Antitumor Assays

Source

Identifiers

PMID: 24473991
DOI: 10.1002/ijc.28574

Genes

WWOX
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

New syngeneic inflammatory-related lung cancer metastatic model harboring double KRAS/WWOX alterations.PMID 24473991Read ↗

Modeling Molecular Pathogenesis of Idiopathic Pulmonary Fibrosis-Associated Lung Cancer in MiceSemantic proximity Read ↗

Combinatorial tumor suppressor inactivation efficiently initiates lung adenocarcinoma with therapeutic vulnerabilitiesSemantic proximity Read ↗

Combinatorial Inactivation of Tumor Suppressors Efficiently Initiates Lung Adenocarcinoma with Therapeutic Vulnerabilities.Semantic proximity Read ↗

Transposon Mutagenesis Reveals RBMS3 Silencing as a Promoter of Malignant Progression of BRAFV600E-Driven Lung TumorigenesisSemantic proximity Read ↗

Transposon Mutagenesis Reveals RBMS3 as a Promoter of Malignant Progression of BRAF <sup>V600E</sup> -Driven Lung TumorigenesisSemantic proximity Read ↗

Mouse models for lung cancerSemantic proximity Read ↗

Relationship between Lung Carcinogenesis and Chronic Inflammation in RodentsSemantic proximity Read ↗

Silica-induced chronic inflammation promotes lung carcinogenesis in the context of an immunosuppressive microenvironment.Semantic proximity Read ↗

Transposon Mutagenesis Screen Identifies Potential Lung Cancer Drivers and CUL3 as a Tumor Suppressor.Semantic proximity Read ↗

Primary lung tumors in mice as an aid for understanding, preventing, and treating human adenocarcinoma of the lung.Semantic proximity Read ↗

Comparative RNA‐Seq transcriptome analysis on silica induced pulmonary inflammation and fibrosis in mice silicosis modelSemantic proximity Read ↗

Progress and applications of mouse models for human lung cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.