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Article

PINK1 and Parkin complementarily protect dopaminergic neurons in vertebrates.

Human molecular genetics - 15 Jun 2013

Matsui Hideaki, Gavinio Roberto, Asano Takeshi, Uemura Norihito, Ito Hidefumi, Taniguchi Yoshihito, Kobayashi Yoshito, Maki Takakuni, Shen Jie, Takeda Shunichi, Uemura Kengo, Yamakado Hodaka, Takahashi Ryosuke

Abstract excerpt

Parkinson's disease (PD) is a common neurodegenerative disorder characterized by selective dopaminergic cell loss in the substantia nigra, but its pathogenesis remains unclear. The recessively inherited familial PD genes PARK2 and PARK6 have been attributed to mutations in the Parkin and PTEN-induced kinase 1 (PINK1) genes, respectively. Recent reports suggest that PINK1 works upstream of Parkin in the same...

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Source

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Identifiers

PMID: 23449626
DOI: 10.1093/hmg/ddt095
PMCID: PMC10259650

Genes

PINK1
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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