Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MiR-375 Promotes Redifferentiation of Adult Human β Cells Expanded In Vitro

13 Apr 2015

Abstract excerpt

In-vitro expansion of β cells from adult human pancreatic islets could provide abundant cells for cell replacement therapy of diabetes. However, proliferation of β-cell-derived (BCD) cells is associated with dedifferentiation. Here we analyzed changes in microRNAs (miRNAs) during BCD cell dedifferentiation and identified miR-375 as one of the miRNAs greatly downregulated. We hypothesized that restoration of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Pancreatic function and diabetes

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 25875172
DOI: 10.1371/journal.pone.0122108

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MiR-375 Promotes Redifferentiation of Adult Human β Cells Expanded In VitroPMID 25875172Read ↗

Insulin-Producing Cells Generated from Dedifferentiated Human Pancreatic Beta Cells Expanded In VitroSemantic proximity Read ↗

MiRNA-375 promotes beta pancreatic differentiation in human induced pluripotent stem (hiPS) cells.Semantic proximity Read ↗

Pancreatic islet differentiation of human embryonic stem cells by microRNA overexpressionSemantic proximity Read ↗

Redifferentiation of Expanded Human Pancreatic β-Cell-derived Cells by Inhibition of the NOTCH PathwaySemantic proximity Read ↗

miR-7 Modulates hESC Differentiation into Insulin-Producing Beta-like Cells and Contributes to Cell MaturationSemantic proximity Read ↗

The role of microRNAs in islet β‐cell developmentSemantic proximity Read ↗

The emerging role of miR‐375 in cancerSemantic proximity Read ↗

miR-375 gene dosage in pancreatic β-cells: implications for regulation of β-cell mass and biomarker developmentSemantic proximity Read ↗

Expansion and redifferentiation of adult human pancreatic islet cells.Semantic proximity Read ↗

Loss of β-cell identity in diabetes : significance of miR-7-mediated chromatin remodellingSemantic proximity Read ↗

Incomplete Re‐Expression of Neuroendocrine Progenitor/Stem Cell Markers is a Key Feature of β‐Cell DedifferentiationSemantic proximity Read ↗

The small RNA miR-375 – a pancreatic islet abundant miRNA with multiple roles in endocrine beta cell functionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.