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Article

Taming the Hippo: Raf-1 controls apoptosis by suppressing MST2/Hippo.

Cell cycle (Georgetown, Tex.) - 1 Mar 2005

O'Neill Eric, Kolch Walter

Abstract excerpt

The Raf-1 kinase has a well established role in activating the MEK-ERK/MAPK pathway. However, accumulating evidence including the phenotype of Raf-1(-/-) mice suggested that Raf-1 may have other functions independent of its role as MEK activator, in particular pertaining to protection against apoptosis. We have recently demonstrated a new role of Raf-1 by showing that Raf-1 controls the proapoptotic kinase...

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Source

Identifiers

PMID: 15701972
DOI: 10.4161/cc.4.3.1531

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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