Article
Matrix metalloproteinase-20 over-expression is detrimental to enamel development: a Mus musculus model.
PloS one - 1 Jan 2014
Shin Masashi, Hu Yuanyuan, Tye Coralee E, Guan Xiaomu, Deagle Craig C, Antone Jerry V, Smith Charles E, Simmer James P, Bartlett John D
Abstract excerpt
BACKGROUND: Matrix metalloproteinase-20 (Mmp20) ablated mice have enamel that is thin and soft with an abnormal rod pattern that abrades from the underlying dentin. We asked if introduction of transgenes expressing Mmp20 would revert this Mmp20 null phenotype back to normal. Unexpectedly, for transgenes expressing medium or high levels of Mmp20, we found opposite enamel phenotypes depending on the genetic...
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