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Article

Family-based gene-environment interaction using sequence kernel association test (FGE-SKAT) for complex quantitative traits.

Scientific reports - 1 Apr 2021

Guo Chao-Yu, Wang Reng-Hong, Yang Hsin-Chou

Abstract excerpt

After the genome-wide association studies (GWAS) era, whole-genome sequencing is highly engaged in identifying the association of complex traits with rare variations. A score-based variance-component test has been proposed to identify common and rare genetic variants associated with complex traits while quickly adjusting for covariates. Such kernel score statistic allows for familial dependencies and adjusts for...

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Identifiers

PMID: 33795796
DOI: 10.1038/s41598-021-86871-2
PMCID: PMC8016937

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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