Article
[Personalized medicine in transplantation therapy].
Rinsho byori. The Japanese journal of clinical pathology - 1 May 2013
Nakatani Kaname
Abstract excerpt
Personalized medicine based on pharmacogenomics is being developed at the clinical stage. Various evidence is accumulating in transplantation therapy. Tacrolimus, a calcineurin inhibitor, is usually used for immunosuppressive therapy after transplantation. Tacrolimus is mainly metabolized by cytochrome P450 isozymes, CYP3A4 and CYP3A5, expressed in the intestine as well as in the liver. Recent studies of...
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