Genomic epidemiological analysis identifies high relapse among individuals with recurring tuberculosis and provides evidence of recent household-related transmission of tuberculosis in Ghana.

doi:10.1016/j.ijid.2021.02.110

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Genomic epidemiological analysis identifies high relapse among individuals with recurring tuberculosis and provides evidence of recent household-related transmission of tuberculosis in Ghana.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases - 1 May 2021

Asare Prince, Osei-Wusu Stephen, Baddoo Nyonuku Akosua, Bedeley Edmund, Otchere Isaac Darko, Brites Daniela, Loiseau Chloé, Asante-Poku Adwoa, Prah Diana Ahu, Borrell Sonia, Reinhard Miriam, Omari Michael Amo, Forson Audrey, Koram Kwadwo Ansah, Gagneux Sebastien, Yeboah-Manu Dorothy

Abstract excerpt

OBJECTIVE: To retrospectively investigate the cause of recurring tuberculosis (rcTB) among participants with pulmonary TB recruited from a prospective population-based study conducted between July 2012 and December 2015. METHODS: Mycobacterium tuberculosis complex isolates obtained from rcTB cases were characterized by standard mycobacterial genotyping tools, whole-genome sequencing, and phylogenetic analysis...

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PMID: 33667696
DOI: 10.1016/j.ijid.2021.02.110
PMCID: PMC8134059

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