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Article

A promoter polymorphism of the alpha 8 integrin gene and the progression of autosomal-dominant polycystic kidney disease.

Nephron. Clinical practice - 1 Jan 2008

Zeltner Raoul, Hilgers Karl F, Schmieder Roland E, Porst Markus, Schulze Bernd D, Hartner Andrea

Abstract excerpt

BACKGROUND/AIMS: Dysregulation of integrins is a feature of tissue remodeling in autosomal-dominant polycystic kidney disease (ADPKD). The alpha 8 beta 1 integrin (alpha8beta1) affects kidney development and the susceptibility to renal injury in mice. We investigated whether the -414 T/C polymorp...

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Source

Identifiers

PMID: 18277079
DOI: 10.1159/000116887

Genes

ITGA8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18277079-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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