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Article

Integrin α3 negative podocytes: A gene expression study

11 Aug 2022

Abstract excerpt

Integrin α3β1 is a cell adhesion receptor widely expressed in epithelial cells. Pathogenic variants in the gene encoding the integrin α3 subunit ITGA3 lead to a syndrome including interstitial lung disease, nephrotic syndrome, and epidermolysis bullosa (ILNEB). Renal involvement mainly consists of glomerular disease caused by loss of adhesion between podocytes and the glomerular basement membrane. The aim of this...

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PMID: 36060790
DOI: 10.1016/j.mbplus.2022.100119

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