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Molecular Evolution of Multiple Forms of Kisspeptins and GPR54 Receptors in Vertebrates

22 Jan 2009

Abstract excerpt

Kisspeptin and its receptor GPR54 play important roles in mammalian reproduction and cancer metastasis. Because the KiSS and GPR54 genes have been identified in a limited number of vertebrate species, mainly in mammals, the evolutionary history of these genes is poorly understood. In the present study, we have cloned multiple forms of kisspeptin and GPR54 cDNAs from a variety of vertebrate species. We found that...

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PMID: 19164475
DOI: 10.1210/en.2008-1679

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