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Article

Identification of fidelity-determined residues of Porcine reproductive and respiratory syndrome virus through structural alignment.

Virulence - 1 Dec 2026

Gao Xiang, Zhang Junnan, Gao Peng, Ge Xinna, Zhang Yongning, Han Jun, Guo Xin, Zhou Lei, Yang Hanchun

Abstract excerpt

Porcine reproductive and respiratory syndrome virus(PRRSV) is an economically important pathogen for global pork industry. As a positive-strand RNA virus, lacking exonuclease-mediated proofreading, its RNA-dependent RNA polymerase (RdRP) domain within the nonstructural protein 9(nsp9) plays a vital role in maintaining replication accuracy. To identify the residues of PRRSV that regulates replication fidelity, its...

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Identifiers

PMID: 41649343
DOI: 10.1080/21505594.2026.2629134
PMCID: PMC12915816

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