Article
Hoxb1b controls oriented cell division, cell shape and microtubule dynamics in neural tube morphogenesis.
Development (Cambridge, England) - 1 Feb 2014
Zigman Mihaela, Laumann-Lipp Nico, Titus Tom, Postlethwait John, Moens Cecilia B
Abstract excerpt
Hox genes are classically ascribed to function in patterning the anterior-posterior axis of bilaterian animals; however, their role in directing molecular mechanisms underlying morphogenesis at the cellular level remains largely unstudied. We unveil a non-classical role for the zebrafish hoxb1b gene, which shares ancestral functions with mammalian Hoxa1, in controlling progenitor cell shape and oriented cell...
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