Article
Cigarettes, genetic background, and menopausal timing: the presence of single nucleotide polymorphisms in cytochrome P450 genes is associated with increased risk of natural menopause in European-American smokers.
Menopause (New York, N.Y.) - 1 Jul 2014
Butts Samantha F, Sammel Mary D, Greer Christine, Rebbeck Timothy R, Boorman David W, Freeman Ellen W
Abstract excerpt
OBJECTIVE: This study aims to evaluate associations between variations in genes involved in the metabolism of environmental chemicals and steroid hormones and risk of menopause in smokers. METHODS: Survival analysis was performed on 410 eligible participants from the Penn Ovarian Aging study (ongoing for 14 years), a cohort study of late-reproductive-age women. Single nucleotide polymorphisms at the following...
Topics
- Adult
- Cohort Studies
- Cytochrome P-450 Enzyme System
- Female
- Genetic Variation
- Hot Flashes
- Humans
- Menopause
- Middle Aged
- Polymorphism, Single Nucleotide