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Article

β-CateninC429S mice exhibit sterility consequent to spatiotemporally sustained Wnt signalling in the internal genitalia.

Scientific reports - 7 Nov 2014

Murata Takuya, Ishitsuka Yuichi, Karouji Kumiko, Kaneda Hideki, Toki Hideaki, Nakai Yuji, Makino Shigeru, Fukumura Ryutaro, Kotaki Hayato, Wakana Shigeharu, Noda Tetsuo, Gondo Yoichi

Abstract excerpt

Wnt/β-catenin signalling regulates numerous developmental and homeostatic processes. Ctnnb1 (also known as β-catenin) is the only protein that transmits signals from various Wnt ligands to downstream genes. In this study, we report that our newly established mouse strain, which harbours a Cys429 to Ser missense mutation in the β-catenin gene, exhibited specific organ defects in contrast to mice with broadly...

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Identifiers

PMID: 25376241
DOI: 10.1038/srep06959
PMCID: PMC4223658

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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