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Article

WNT signalling in the normal human adult testis and in male germ cell neoplasms

2 Jun 2020

Abstract excerpt

STUDY QUESTION: Is WNT signalling functional in normal and/or neoplastic human male germ cells? SUMMARY ANSWER: Regulated WNT signalling component synthesis in human testes indicates that WNT pathway function changes during normal spermatogenesis and is active in testicular germ cell tumours (TGCTs), and that WNT pathway blockade may restrict seminoma growth and migration. WHAT IS KNOWN ALREADY: Regulated WNT...

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PMID: 32667987
DOI: 10.1093/humrep/deaa150

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