Article
Genetic variation in Fcgamma receptor IIa protects against advanced peripheral atherosclerosis. The Rotterdam Study.
Thrombosis and haemostasis - 1 Dec 2004
van der Meer Irene M, Witteman Jacqueline C M, Hofman Albert, Kluft Cornelis, de Maat Moniek P M
Abstract excerpt
Immune processes play a substantial role in atherosclerotic disease. The role in atherosclerosis of Fcgamma receptor IIa (FcgammaRIIa), a receptor for immunoglobulin G and for the inflammatory mediator C-reactive protein, is not yet clear. Since the R/H131 polymorphism in the FcgammaRIIa gene strongly influences binding to FcgammaRIIa, we investigated the association of the R/H131 polymorphism with advanced...
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