Article
Multilocus genetic risk score associates with ischemic stroke in case-control and prospective cohort studies.
Stroke - 1 Feb 2014
Malik Rainer, Bevan Steve, Nalls Michael A, Holliday Elizabeth G, Devan William J, Cheng Yu-Ching, Ibrahim-Verbaas Carla A, Verhaaren Benjamin F J, Bis Joshua C, Joon Aron Y, de Stefano Anita L, Fornage Myriam, Psaty Bruce M, Ikram M Arfan, Launer Lenore J, van Duijn Cornelia M, Sharma Pankaj, Mitchell Braxton D, Rosand Jonathan, Meschia James F, Levi Christopher, Rothwell Peter M, Sudlow Cathie, Markus Hugh S, Seshadri Sudha, Dichgans Martin
Abstract excerpt
BACKGROUND AND PURPOSE: Genome-wide association studies have revealed multiple common variants associated with known risk factors for ischemic stroke (IS). However, their aggregate effect on risk is uncertain. We aimed to generate a multilocus genetic risk score (GRS) for IS based on genome-wide association studies data from clinical-based samples and to establish its external validity in prospective...
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