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Article

Alleviation of neuronal ganglioside storage does not improve the clinical course of the Niemann-Pick C disease mouse.

Human molecular genetics - 12 Apr 2000

Liu Y, Wu Y P, Wada R, Neufeld E B, Mullin K A, Howard A C, Pentchev P G, Vanier M T, Suzuki K, Proia R L

Abstract excerpt

Niemann-Pick disease Type C (NP-C) is a progressive neurodegenerative disorder caused by mutations in the NPC1 gene and characterized by intracellular accumulation of cholesterol and sphingo-lipids. The major neuronal storage material in NP-C consists of gangliosides and other glycolipids, raising the possibility that the accumulation of these lipids may participate in the neurodegenerative process. To determine...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10767333
DOI: 10.1093/hmg/9.7.1087

Genes

NPC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Alleviation of neuronal ganglioside storage does not improve the clinical course of the Niemann-Pick C disease mouse.PMID 10767333Read ↗

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