Article
Plasmacytoid Dendritic Cells Mediate Control of Ross River Virus Infection via a Type I Interferon-Dependent, MAVS-Independent Mechanism.
Journal of virology - 24 Feb 2021
Haist Kelsey C, Carpentier Kathryn S, Davenport Bennett J, Morrison Thomas E
Abstract excerpt
Ross River virus (RRV) is a mosquito-borne alphavirus that causes epidemics of debilitating musculoskeletal disease. To define the innate immune mechanisms that mediate control of RRV infection, we studied a RRV strain encoding 6 nonsynonymous mutations in nsP1 (RRV-T48-nsP16M) that is attenuated in wild-type (WT) mice and Rag1-/- mice, which are unable to mount adaptive immune responses, but not in mice that...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
