Article

Mutations in SARS-CoV-2 Nsp1 are critical determinants of viral pathogenicity in mice

2026-08-17

Abstract excerpt

<h4>ABSTRACT</h4> Severe Acute Respiratory Coronavirus 2 (SARS-CoV-2) nonstructural protein 1 (Nsp1) dampens the host immune response by shutting off host gene expression, a strategy that has remained evolutionary conserved among a diverse range of coronaviruses (CoVs). Residues important for SARS-CoV-2 Nsp1 mediated host shutoff have been incompletely defined. We have generated and characterized the ability of f...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f2844dc5-9476-5d18-9e65-84b8d15906fb
DOI: 10.64898/2026.08.14.744970

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Mutations in SARS-CoV-2 Nsp1 are critical determinants of viral pathogenicity in miceDOI 10.64898/2026.08.14.744970Read

Deletion of a KSF Motif Attenuates NSP1 Host Cell Translation Shutoff and Impairs SARS-CoV-2 VirulenceSemantic proximity Read

SARS-CoV-2 Nsp2 reprograms host immunity to drive pathogenic inflammationSemantic proximity Read

Naturally occurring N-terminal mutations in SARS-CoV-2 nsp1 impact innate immune modulation but do not affect virus virulenceSemantic proximity Read

A comprehensive review of current insights into the virulence factors of SARS-CoV-2.Semantic proximity Read

Multiple layers of innate immune response antagonism of SARS-CoV-2Semantic proximity Read

Immunization with recombinant accessory protein-deficient SARS-CoV-2 protects against lethal challenge and viral transmissionSemantic proximity Read

Differential pathogenesis of SARS-CoV-2 variants of concern in human ACE2-expressing miceSemantic proximity Read

Structure of nonstructural protein 1 from SARS-CoV-2Semantic proximity Read

Redundant and distinct mechanisms suppress innate immune activation during SARS-CoV-2 infection.Semantic proximity Read

Dissecting Phenotype from Genotype with Clinical Isolates of SARS-CoV-2 First Wave Variants.Semantic proximity Read

SARS-CoV-2 ORF8 modulates lung inflammation and clinical disease progression.Semantic proximity Read

Coronavirus Nsp1: Immune Response Suppression and Protein Expression InhibitionSemantic proximity Read