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Article

Severe obstructive sleep apnea in a child with melanocortin-4 receptor deficiency.

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine - 15 Jan 2014

Pillai Sophia, Nandalike Kiran, Kogelman Yelena, Muzumdar Radhika, Balk Sophie J, Arens Raanan

Abstract excerpt

Obstructive sleep apnea (OSA) is a highly prevalent medical condition in obese children and is associated with significant neurocognitive, cardiovascular and metabolic derangements. Monogenic forms of obesity resulting from disruption of the leptin-melanocortin pathways have become more notable in recent years and distinguish between various obese phenotypes. However, the association of such disorders with OSA is...

Topics

Body Mass Index
Female
Humans
Mutation
Obesity, Morbid
Polysomnography
Receptor, Melanocortin, Type 4
Risk Factors
Sleep Apnea, Obstructive

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Identifiers

PMID: 24426828
DOI: 10.5664/jcsm.3374
PMCID: PMC3869078

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-24426828-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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