Article
Association of genetic variants in apoptosis genes FAS and FASL with radiation-induced late toxicity after prostate cancer radiotherapy.
Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] - 1 Mar 2014
Thurner E-M, Krenn-Pilko S, Langsenlehner U, Renner W, Gerger A, Kapp K S, Langsenlehner T
Abstract excerpt
BACKGROUND AND PURPOSE: Fas ligand (FASL) triggers apoptotic cell death by cross-linking with its receptor FAS, and after irradiation, expression of FAS and FASL is increased. In the present study, we investigated the association between common polymorphisms in the genes for FAS and FASL and the risk of late side effects after radiotherapy for prostate cancer. PATIENTS AND METHODS: The role of FAS (- 1377G > A,...
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