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Article

Structural mechanism of DNA recognition by the p202 HINa domain: insights into the inhibition of Aim2-mediated inflammatory signalling.

Acta crystallographica. Section F, Structural biology communications - 1 Jan 2014

Li He, Wang Jue, Wang Jie, Cao Lu-Sha, Wang Zhi-Xin, Wu Jia-Wei

Abstract excerpt

The HIN-200 family of proteins play significant roles in inflammation-related processes. Among them, AIM2 (absent in melanoma 2) and IFI16 (γ-interferon-inducible protein 16) recognize double-stranded DNA to initiate inflammatory responses. In contrast, p202, a mouse interferon-inducible protein containing two HIN domains (HINa and HINb), has been reported to inhibit Aim2-mediated inflammatory signalling in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24419611
DOI: 10.1107/S2053230X1303135X
PMCID: PMC3943098

Genes

AIM2
IFI16

Provenance

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