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Article

Gene context analysis reveals functional divergence between hypothetically equivalent enzymes of the purine-ureide pathway.

Biochemistry - 4 Feb 2014

Puggioni Vincenzo, Dondi Ambra, Folli Claudia, Shin Inchul, Rhee Sangkee, Percudani Riccardo

Abstract excerpt

A major problem of genome annotation is the assignment of a function to a large number of genes of known sequences through comparison with a relatively small number of experimentally characterized genes. Because functional divergence is a widespread phenomenon in gene evolution, the transfer of a...

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PMID: 24417435
DOI: 10.1021/bi4010107

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24417435-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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