An aminotransferase branch point connects purine catabolism to amino acid recycling.

Abstract excerpt

Although amino acids are known precursors of purines, a pathway for the direct recycling of amino acids from purines has never been described at the molecular level. We provide NMR and crystallographic evidence that the PucG protein from Bacillus subtilis catalyzes the transamination between an unstable intermediate ((S)-ureidoglycine) and the end product of purine catabolism (glyoxylate) to yield oxalurate and...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Alanine
• Share to Bacillus subtilis