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The Structure and Function of a Microbial Allantoin Racemase Reveal the Origin and Conservation of a Catalytic Mechanism.

Biochemistry - 22 Nov 2016

Cendron Laura, Ramazzina Ileana, Puggioni Vincenzo, Maccacaro Eleonora, Liuzzi Anastasia, Secchi Andrea, Zanotti Giuseppe, Percudani Riccardo

Abstract excerpt

The S enantiomer of allantoin is an intermediate of purine degradation in several organisms and the final product of uricolysis in nonhominoid mammals. Bioinformatics indicated that proteins of the Asp/Glu racemase superfamily could be responsible for the allantoin racemase (AllR) activity originally described in Pseudomonas species. In these proteins, a cysteine of the catalytic dyad is substituted with glycine,...

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PMID: 27797489
DOI: 10.1021/acs.biochem.6b00881

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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