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Article

Sequence variation and conservation in virulence-related genes of Bordetella pertussis isolates from the UK.

Journal of medical microbiology - 1 May 2004

Packard Erica R, Parton Roger, Coote John G, Fry Norman K

Abstract excerpt

To determine the value of gene markers for surveillance and to assess the genetic stability of potential acellular pertussis vaccine components, the sequence variation in ten virulence-related genes of Bordetella pertussis was investigated in strains isolated in the UK between 1920 and 2002. These genes encode: pertactin (prnA); pertussis toxin subunits S1 (ptxA) and S3 (ptxC); tracheal colonization factor...

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Identifiers

PMID: 15096543
DOI: 10.1099/jmm.0.05515-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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