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Article

Structural determinants of the 5'-methylthioinosine specificity of Plasmodium purine nucleoside phosphorylase.

PloS one - 1 Jan 2014

Donaldson Teraya M, Ting Li-Min, Zhan Chenyang, Shi Wuxian, Zheng Renjian, Almo Steven C, Kim Kami

Abstract excerpt

Plasmodium parasites rely upon purine salvage for survival. Plasmodium purine nucleoside phosphorylase is part of the streamlined Plasmodium purine salvage pathway that leads to the phosphorylysis of both purines and 5'-methylthiopurines, byproducts of polyamine synthesis. We have explored structural features in Plasmodium falciparum purine nucleoside phosphorylase (PfPNP) that affect efficiency of catalysis as...

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Identifiers

PMID: 24416224
DOI: 10.1371/journal.pone.0084384
PMCID: PMC3885546

Genes

PNP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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