Article
The molecular structure of Schistosoma mansoni PNP isoform 2 provides insights into the nucleoside selectivity of PNPs.
PloS one - 1 Jan 2018
Torini Juliana Roberta, Romanello Larissa, Batista Fernanda Aparecida Heleno, Serrão Vitor Hugo Balasco, Faheem Muhammad, Zeraik Ana Eliza, Bird Louise, Nettleship Joanne, Reddivari Yamini, Owens Ray, DeMarco Ricardo, Borges Júlio César, Brandão-Neto José, Pereira Humberto D'Muniz
Abstract excerpt
Purine nucleoside phosphorylases (PNPs) play an important role in the blood fluke parasite Schistosoma mansoni as a key enzyme of the purine salvage pathway. Here we present the structural and kinetic characterization of a new PNP isoform from S. mansoni, SmPNP2. Thermofluorescence screening of different ligands suggested cytidine and cytosine are potential ligands. The binding of cytosine and cytidine were...
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