Article
Severe retinal degeneration caused by a novel rhodopsin mutation.
Investigative ophthalmology & visual science - 1 Feb 2010
Liu Haiquan, Wang Meng, Xia Chun-Hong, Du Xin, Flannery John G, Ridge Kevin D, Beutler Bruce, Gong Xiaohua
Abstract excerpt
PURPOSE: To identify a new mouse mutation developing early-onset dominant retinal degeneration, to determine the causative gene mutation, and to investigate the underlying mechanism. METHODS: Retinal phenotype was examined by indirect ophthalmoscopy, histology, transmission electron microscopy, immunohistochemistry, Western blot analysis, and electroretinography. Causative gene mutation was determined by...
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