Article
Alterations in classical and nonclassical HLA expression in recurrent and progressive HPV-induced usual vulvar intraepithelial neoplasia and implications for immunotherapy.
International journal of cancer - 15 Aug 2014
van Esch E M G, Tummers B, Baartmans V, Osse E M, Ter Haar N, Trietsch M D, Hellebrekers B W J, Holleboom C A G, Nagel H T C, Tan L T, Fleuren G J, van Poelgeest M I E, van der Burg S H, Jordanova E S
Abstract excerpt
Immunotherapy of usual vulvar intraepithelial neoplasia (uVIN) is promising; however, many patients still fail to show clinical responses, which could be explained by an immune escape through alterations in human leukocyte antigen (HLA) expression. Therefore, we analyzed a cohort of patients with a primary (n = 43) and subsequent recurrent uVIN lesion (n = 20), vaccine-treated uVIN patients (n = 12), patients...
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