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Article

LIG4 and RAD52 DNA repair genes polymorphisms and systemic lupus erythematosus.

Molecular biology reports - 1 Jan 2014

De Azevêdo Silva Jaqueline, Pancotto João Alexandre Trés, Donadi Eduardo Antônio, Crovella Sergio, Sandrin-Garcia Paula

Abstract excerpt

Systemic lupus erythematosus (SLE) is a complex autoimmune disorder with a strong genetic background. Nevertheless, SLE might also be triggered due to environmental factors, such as UV light exposure. DNA double strand breaks (DSBs) may be induced secondarily by UV radiation, increasing DNA immunogenicity and in SLE patients DNA repair is diminished, allowing the accumulation of DSBs and genomic instability. LIG4...

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Source

Identifiers

PMID: 24415301
DOI: 10.1007/s11033-014-3076-y

Genes

LIG4
RAD52

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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