Article
Genetic predictors of antidepressant side effects: a grouped candidate gene approach in the Genome-Based Therapeutic Drugs for Depression (GENDEP) study.
Journal of psychopharmacology (Oxford, England) - 1 Feb 2014
Hodgson Karen, Uher Rudolf, Crawford Andrew A, Lewis Glyn, O'Donovan Michael C, Keers Robert, Dernovsek Mojca Z, Mors Ole, Hauser Joanna, Souery Daniel, Maier Wolfgang, Henigsberg Neven, Rietschel Marcella, Placentino Anna, Aitchison Katherine, Farmer Anne, Davis Oliver, McGuffin Peter
Abstract excerpt
BACKGROUND: The unwanted side effects associated with antidepressants are key determinants of treatment adherence in depression; propensity to experience these adverse drug reactions (ADRs) may be influenced by genetic variation. However, previous work attempting to ascertain the genetic variants involved has had limited success, in part due to the range of ADRs reported with antidepressants. METHOD: ADRs...
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