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Inflammation-associated microsatellite alterations: Mechanisms and significance in the prognosis of patients with colorectal cancer

12 Jan 2018

Abstract excerpt

Microsatellite alterations within genomic DNA frameshift as a result of defective DNA mismatch repair (MMR). About 15% of sporadic colorectal cancers (CRCs) manifest hypermethylation of the DNA MMR gene MLH1 , resulting in mono-and di-nucleotide frameshifts to classify it as microsatellite instability-high (MSI-H) and hypermutated, and due to frameshifts at coding microsatellites generating neo-antigens, produce...

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PMID: 29375743
DOI: 10.4251/wjgo.v10.i1.1

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