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Article

Positive selection of protective variants for type 2 diabetes from the Neolithic onward: a case study in Central Asia.

European journal of human genetics : EJHG - 1 Oct 2013

Ségurel Laure, Austerlitz Frederic, Toupance Bruno, Gautier Mathieu, Kelley Joanna L, Pasquet Patrick, Lonjou Christine, Georges Myriam, Voisin Sarah, Cruaud Corinne, Couloux Arnaud, Hegay Tatyana, Aldashev Almaz, Vitalis Renaud, Heyer Evelyne

Abstract excerpt

The high prevalence of type 2 diabetes and its uneven distribution among human populations is both a major public health concern and a puzzle in evolutionary biology. Why is this deleterious disease so common, while the associated genetic variants should be removed by natural selection? The 'thrifty genotype' hypothesis proposed that the causal genetic variants were advantageous and selected for during the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23340510
DOI: 10.1038/ejhg.2012.295
PMCID: PMC3778335

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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