Article
Revealing phenotype-associated functional differences by genome-wide scan of ancient haplotype blocks.
PloS one - 1 Jan 2017
Onuki Ritsuko, Yamaguchi Rui, Shibuya Tetsuo, Kanehisa Minoru, Goto Susumu
Abstract excerpt
Genome-wide scans for positive selection have become important for genomic medicine, and many studies aim to find genomic regions affected by positive selection that are associated with risk allele variations among populations. Most such studies are designed to detect recent positive selection. However, we hypothesize that ancient positive selection is also important for adaptation to pathogens, and has affected...
Topics
- Databases, Genetic
- Genetics, Population
- Genome, Human
- Genome-Wide Association Study
- Genotype
- HapMap Project
- Haplotypes
- Humans
- Linkage Disequilibrium
- Metabolic Diseases
- Monte Carlo Method
- Multigene Family
- Neoplasms
- Neurodegenerative Diseases
- Phenotype
- Polymorphism, Single Nucleotide