β-Aminoisobutyric acid induces browning of white fat and hepatic β-oxidation and is inversely correlated with cardiometabolic risk factors.

doi:10.1016/j.cmet.2013.12.003

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Article

β-Aminoisobutyric acid induces browning of white fat and hepatic β-oxidation and is inversely correlated with cardiometabolic risk factors.

Cell metabolism - 7 Jan 2014

Roberts Lee D, Boström Pontus, O'Sullivan John F, Schinzel Robert T, Lewis Gregory D, Dejam Andre, Lee Youn-Kyoung, Palma Melinda J, Calhoun Sondra, Georgiadi Anastasia, Chen Ming-Huei, Ramachandran Vasan S, Larson Martin G, Bouchard Claude, Rankinen Tuomo, Souza Amanda L, Clish Clary B, Wang Thomas J, Estall Jennifer L, Soukas Alexander A, Cowan Chad A, Spiegelman Bruce M, Gerszten Robert E

Abstract excerpt

The transcriptional coactivator peroxisome proliferator-activated receptor-gamma coactivator-1α (PGC-1α) regulates metabolic genes in skeletal muscle and contributes to the response of muscle to exercise. Muscle PGC-1α transgenic expression and exercise both increase the expression of thermogenic genes within white adipose. How the PGC-1α-mediated response to exercise in muscle conveys signals to other tissues...

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PMID: 24411942
DOI: 10.1016/j.cmet.2013.12.003
PMCID: PMC4017355

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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