Article
Transposable hypomethylation is associated with metastatic capacity of primary melanomas.
International journal of clinical and experimental pathology - 1 Jan 2013
Ecsedi Szilvia I, Hernandez-Vargas Hector, Lima Sheila C, Herceg Zdenko, Adany Roza, Balazs Margit
Abstract excerpt
Despite the strong progress has been made in the field of melanoma epigenetics, the importance of genome-wide demethylation or hypomethylation remains underestimated. However, this phenomenon might also reflect important epigenetic alterations due to its ability to cause genetic instability. Furthermore, no methylation-based distinction has been drawn among the diverse primary melanoma subtypes. To assess global...
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