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Article

Polymorphisms of the Toll-Like Receptor-3 Gene in Autoimmune Adrenal Failure and Type 1 Diabetes in Polish Patients.

Archivum immunologiae et therapiae experimentalis - 1 Feb 2016

Fichna Marta, Żurawek Magdalena, Fichna Piotr, Januszkiewicz-Lewandowska Danuta, Ruchała Marek, Nowak Jerzy

Abstract excerpt

Infectious agents are plausible environmental triggers for autoimmunity in genetically susceptible individuals. Polymorphic variants of genes implicated in innate immunity may affect immune responses and hence promote auto-aggressive reactions. Genes such as Toll-like receptor-3 (TLR3), which participate in recognizing conserved foreign molecules and mounting the first line of defence against viral infections,...

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Source

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Identifiers

PMID: 26318769
DOI: 10.1007/s00005-015-0360-z
PMCID: PMC4713709

Genes

TLR3

Provenance

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