Article
High EGFR gene copy number predicts poor outcome in triple-negative breast cancer.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Sept 2014
Park Heae Surng, Jang Min Hye, Kim Eun Joo, Kim Hyun Jeong, Lee Hee Jin, Kim Yu Jung, Kim Jee Hyun, Kang Eunyoung, Kim Sung-Won, Kim In Ah, Park So Yeon
Abstract excerpt
Epidermal growth factor receptor (EGFR) is frequently overexpressed in triple-negative breast cancer and is emerging as a therapeutic target. EGFR gene copy number alteration and mutation are highly variable and scientists have been challenged to define their prognostic significance in triple-negative breast cancer. We examined EGFR protein expression, EGFR gene copy number alteration and mutation of exon 18 to...
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