Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ALK protein expression and gene copy number alterations in triple-negative breast cancer: Clinical implications.

Human pathology - 1 Jul 2026

Qiu Yuhan, Wang Jingyuan, Jiao Wanting, Wei Roufan, Li Jiajia, Zhang Wei

Abstract excerpt

Anaplastic lymphoma kinase (ALK) is a well-established oncogenic driver in non-small cell lung cancer (NSCLC), but its role in triple-negative breast cancer (TNBC) remains largely unexplored. In this study, we examined the expression and gene status of ALK in 208 TNBC cases using immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH). ALK protein positivity was identified in 19.2% of cases,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Anaplastic Lymphoma Kinase
Share to Biomarkers, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Copy Number Variations

Share to Gene Dosage

Share to Immunohistochemistry

Share to In Situ Hybridization, Fluorescence

Share to Triple Negative Breast Neoplasms

Source

Identifiers

PMID: 41932508
DOI: 10.1016/j.humpath.2026.106115

Genes

ALK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ALK protein expression and gene copy number alterations in triple-negative breast cancer: Clinical implications.PMID 41932508Read ↗

ALK alteration is a frequent event in aggressive breast cancers.Semantic proximity Read ↗

ALK gene alterations in cancer: biological aspects and therapeutic implications.Semantic proximity Read ↗

Genetic instability and recurrent MYC amplification in ALK-translocated NSCLC: a central role of TP53 mutations.Semantic proximity Read ↗

Integrated analysis of the clinical consequence and associated gene expression of ALK in ALK-positive human cancersSemantic proximity Read ↗

The molecular detection and clinical significance of ALK rearrangement in selected advanced non-small cell lung cancer: ALK expression provides insights into ALK targeted therapy.Semantic proximity Read ↗

An activating ALK gene mutation in ALK IHC-positive/FISH-negative nonsmall-cell lung cancer.Semantic proximity Read ↗

Anaplastic Lymphoma Kinase (ALK) Receptor Tyrosine Kinase: A Catalytic Receptor with Many FacesSemantic proximity Read ↗

Analysis of the Genomic Landscape in ALK+ NSCLC Patients Identifies Novel Aberrations Associated with Clinical Outcomes.Semantic proximity Read ↗

High EGFR gene copy number predicts poor outcome in triple-negative breast cancer.Semantic proximity Read ↗

A new look at the ALK gene in cancer: copy number gain and amplificationSemantic proximity Read ↗

Correlating p53 immunostaining patterns with somatic TP53 mutation and functional properties of mutant p53 in triple‐negative breast cancerSemantic proximity Read ↗

ALK-positive large B-cell lymphoma: a clinicopathological and molecular characteristics analysis of seven cases.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.