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Article

Epidermal growth factor receptor copy number alterations correlate with poor clinical outcome in patients with head and neck squamous cancer.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Jun 2007

Temam Stephane, Kawaguchi Hidetoshi, El-Naggar Adel K, Jelinek Jaroslav, Tang Hongli, Liu Diane D, Lang Wenhua, Issa Jean-Pierre, Lee J Jack, Mao Li

Abstract excerpt

PURPOSE: Overexpression of epidermal growth factor receptor (EGFR) is common in head and neck squamous cell carcinoma (HNSCC). Recent studies showed that EGFR inhibitors are effective for patients with HNSCC. This study analyzed the genetic nature of EGFR gene in HNSCC and its clinical correlations. PATIENTS AND METHODS: The EGFR gene copy numbers in 134 HNSCC tumors were determined using quantitative real-time...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Squamous Cell

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Source

Identifiers

PMID: 17538160
DOI: 10.1200/JCO.2006.06.6605

Genes

EGFR

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Epidermal growth factor receptor copy number alterations correlate with poor clinical outcome in patients with head and neck squamous cancer.PMID 17538160Read ↗

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