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Article

Defects of immune regulation in the presenilin-1 mutant knockin mouse.

Neuromolecular medicine - 1 Jan 2007

Morgan Grant A, Guo Qing, Chan Sic L, Gary Devin S, Osborne Barbara A, Mattson Mark P

Abstract excerpt

Mutations in the presenilin-1 (PS1) gene are causally linked to early-onset Alzheimer's disease (AD). Studies of neurons suggest that PS1 mutations result in a gain-of-function, which perturbs calcium regulation and increases cell vulnerability to apoptosis. Alterations in immune cell function have also been demonstrated in AD, and a role for PS1 in immune regulation has been suggested recently. We now report...

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Source

Identifiers

PMID: 17114823
DOI: 10.1385/nmm:9:1:35

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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