Article
Generation of SNP datasets for orangutan population genomics using improved reduced-representation sequencing and direct comparisons of SNP calling algorithms.
BMC genomics - 10 Jan 2014
Greminger Maja P, Stölting Kai N, Nater Alexander, Goossens Benoit, Arora Natasha, Bruggmann Rémy, Patrignani Andrea, Nussberger Beatrice, Sharma Reeta, Kraus Robert H S, Ambu Laurentius N, Singleton Ian, Chikhi Lounes, van Schaik Carel P, Krützen Michael
Abstract excerpt
BACKGROUND: High-throughput sequencing has opened up exciting possibilities in population and conservation genetics by enabling the assessment of genetic variation at genome-wide scales. One approach to reduce genome complexity, i.e. investigating only parts of the genome, is reduced-representation library (RRL) sequencing. Like similar approaches, RRL sequencing reduces ascertainment bias due to simultaneous...
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