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Article

An SNP map of the human genome generated by reduced representation shotgun sequencing.

Nature - 28 Sept 2000

Altshuler D, Pollara V J, Cowles C R, Van Etten W J, Baldwin J, Linton L, Lander E S

Abstract excerpt

Most genomic variation is attributable to single nucleotide polymorphisms (SNPs), which therefore offer the highest resolution for tracking disease genes and population history. It has been proposed that a dense map of 30,000-500,000 SNPs can be used to scan the human genome for haplotypes associated with common diseases. Here we describe a simple but powerful method, called reduced representation shotgun (RRS)...

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PMID: 11029002
DOI: 10.1038/35035083

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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