Article
An SNP map of the human genome generated by reduced representation shotgun sequencing.
Nature - 28 Sept 2000
Altshuler D, Pollara V J, Cowles C R, Van Etten W J, Baldwin J, Linton L, Lander E S
Abstract excerpt
Most genomic variation is attributable to single nucleotide polymorphisms (SNPs), which therefore offer the highest resolution for tracking disease genes and population history. It has been proposed that a dense map of 30,000-500,000 SNPs can be used to scan the human genome for haplotypes associ...
Topics
- Algorithms
- Chromosome Mapping
- Gene Library
- Genome, Human
- Humans
- Molecular Sequence Data
- Polymorphism, Single Nucleotide
- Sequence Alignment
- Sequence Analysis, DNA