Article
SNP discovery and allele frequency estimation by deep sequencing of reduced representation libraries.
Nature methods - 1 Mar 2008
Van Tassell Curtis P, Smith Timothy P L, Matukumalli Lakshmi K, Taylor Jeremy F, Schnabel Robert D, Lawley Cynthia Taylor, Haudenschild Christian D, Moore Stephen S, Warren Wesley C, Sonstegard Tad S
Abstract excerpt
High-density single-nucleotide polymorphism (SNP) arrays have revolutionized the ability of genome-wide association studies to detect genomic regions harboring sequence variants that affect complex traits. Extensive numbers of validated SNPs with known allele frequencies are essential to construct genotyping assays with broad utility. We describe an economical, efficient, single-step method for SNP discovery,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.