Article
Kcne2 deletion creates a multisystem syndrome predisposing to sudden cardiac death.
Circulation. Cardiovascular genetics - 1 Feb 2014
Hu Zhaoyang, Kant Ritu, Anand Marie, King Elizabeth C, Krogh-Madsen Trine, Christini David J, Abbott Geoffrey W
Abstract excerpt
BACKGROUND: Sudden cardiac death (SCD) is the leading global cause of mortality, exhibiting increased incidence in patients with diabetes mellitus. Ion channel gene perturbations provide a well-established ventricular arrhythmogenic substrate for SCD. However, most arrhythmia-susceptibility genes, including the KCNE2 K(+) channel β subunit, are expressed in multiple tissues, suggesting potential multiplex SCD...
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